However, the presence of these TERT promoter mutations in Langerhans cell histiocytosis (LCH) remains unexplored.<h4>Methods</h4>We investigated the prevalence of TERT promoter C228T and C250T mutations in 40 formalin-fixed, paraffin-embedded (FFPE) LCH samples positive for BRAF V600E. Here, BRAF is linked to Langerhans cell histiocytosis.