A study revealed that ketoconazole, a broad-spectrum antifungal agent, activates PINK1/Parkin-mediated mitophagy by downregulating cyclooxygenase-2, and exerts a synergistic inhibitory effect on HCC when combined with ketoconazole, offering a potential strategy to overcome sorafenib resistance (114). This evidence concerns the gene PINK1 and hepatocellular carcinoma.