The present review outlines the tripartite axis of mitophagy, namely, the PTEN-induced putative kinase 1/Parkin, PI3K/AKT/mTOR and AMP-activated protein kinase pathways, in NAFLD pathogenesis across the various stages of disease development, including steatosis, nonalcoholic steatohepatitis and fibrosis, and explores their therapeutic potential. Here, MTOR is linked to metabolic dysfunction-associated steatotic liver disease.