IGFBP3 and cervical carcinoma: Given that the cells with Inc-FANCI-2 KO exhibit increased levels of IGFBP3 and MCAM, and the ΔPr-A9 cells with rescued lnc-FANCI-2 RNA expression displayed remarkable reduction of IGFBP3 and MCAM expression, our current model (Figure 9E) highlights how the HPV16-enhanced expression of lnc-FANCI-2 in cervical cancer cells might function as a negative regulator by binding to various RNA-binding proteins to block RAS signaling and reduce the expression of RAS signaling effectors such as IGFBP3 and MCAM.