Among the 12 p53 isoforms identified, the Δ133p53 isoforms (Δ133p53α, Δ133p53β, and Δ133p53γ) have been the most widely studied in cancer, with Δ133p53β being the most frequently reported isoform in cancers with poorer patient outcomes [4–9]. Here, TP53 is linked to cancer.