WNK2 and melanoma: All Δ122p53-expressing PDAC and melanomas grew faster than control tumors (Fig. 1a), and, consistent with this, all Δ122p53-expressing tumors showed increased markers of proliferation with more phosphorylated mitogen-activated protein kinase (pMAPK) and ki67-positive cells compared with control cell lines (Fig. 1b and c, respectively).