Apoe+ macrophages, which express Cd206 (Mrc1) and C1qc, have been defined as typical tumor‐associated macrophages (TAMs) with protumor functions in previous studies.[25, 26] In contrast, Cxcl9 and Cxcl10, which are well‐known markers of M1 and proinflammatory differentiation,[27, 28] were found to be upregulated in Ccr2+ macrophages (Figure 1M). Here, APOE is linked to neoplasm.