These findings delineate a novel imaging–transcriptomic relationship between ROCK2 and brain‐wide synaptic changes in TLE, suggesting that ROCK2‐specific inhibitors may regulate synaptic networks by enhancing mitochondrial autophagy and promoting synaptic remodeling in TLE, highlighting their potential as a therapeutic strategy for epilepsy (Scheme1). This evidence concerns the gene ROCK2 and epilepsy.