TBC1D22B and breast cancer: The overarching goal of this study was to delineate the molecular circuitry regulated by TBC1D22B, given its previously demonstrated association with breast cancer (BC) progression – specifically, our earlier findings identified high TBC1D22B expression as an independent predictor of poor prognosis in Luminal BC.[10] To investigate the relevance of the high expression of TBC1D22B in breast carcinogenesis, we employed a dual approach combining high‐resolution in vitro experimentation with high‐throughput bioinformatic analyses of large BC datasets.