For instance, the TBC1D22A paralogue facilitates ER‐to‐Golgi transport of α2B‐adrenergic receptors, whereas TBC1D22B does not.[15] This suggests a possible division of labor between paralogues, with TBC1D22B specializing in the retention or diversion of certain cargos – such as ECM proteins or metabolic enzymes – whose trafficking may influence cancer progression. The gene discussed is TBC1D22B; the disease is cancer.