These findings are consistent with previous reports linking TBC1D22B to metabolic activity in cancer cells[10] and with developmental studies showing that in Drosophila, the TBC1D22B orthologue, dTBC1D22, regulates lipid droplet accumulation.[27] Together these data suggest a possible role of TBC1D22B in coordinating trafficking with metabolic state, which might be subverted in cancer. The gene discussed is TBC1D22B; the disease is cancer.