engineered the attenuated S. typhimurium strain VNP20009 for sonogenetically controlled expression of a PD‐L1 nanobody.[27] The strain, delivered intravenously into multiple murine tumor models, incorporated the Synthetic Interruption of Genes by Excision and Replacement system: a temperature‐sensitive module based on the thermolabile repressor TlpA39. Here, CD274 is linked to neoplasm.