Building on the role of GM‐CSF in promoting dendritic cell/macrophage accumulation and maturation to enhance antigen presentation and T cell priming,[99] combined delivery with PD‐L1 and CTLA‐4 nanobodies targets immune initiation, activation, and effector checkpoints to reprogram the tumor microenvironment for sustained antitumor immunity. This evidence concerns the gene CD274 and neoplasm.