These metabolic changes promoted the polarization of tumor‐associated macrophages from the immunosuppressive M2 macrophages (M2) to the pro‐inflammatory M1 macrophages (M1) phenotype, enhanced dendritic cell maturation, and increased cluster of differentiation 4 positive T cells (CD4+) and cluster of differentiation 8 positive T cells (CD8+)T cell infiltration and activation within the tumor (Figure2a). This evidence concerns the gene CD4 and neoplasm.