PUFAs are essential components of skin structure and function, contributing to membrane integrity and the regulation of inflammatory responses.[16] To investigate the involvement of PUFA biosynthesis in psoriasis, we examined the expression of key enzymes responsible for PUFAs synthesis (Figure 1A), including the desaturases FADS1 and FADS2 and the elongase ELOVL5, using publicly available microarray datasets (accession no. GSE13355 and GSE51440). This evidence concerns the gene ELOVL5 and psoriasis.