PPARA and atopic eczema: It modulates keratinocyte proliferation, differentiation, and cytokine responses, thereby contributing to tissue homeostasis and repair.[58] Topical application of WY14643 has previously been shown to suppress antigen‐induced cutaneous inflammation in an atopic dermatitis model.[59, 60] In line with these reports, we found that PPARA silencing enhanced M5‐induced pro‐inflammatory gene expression in keratinocytes, whereas PPARα activation dampened this response.