Moreover, mice with keratinocyte‐specific Fads2 knockdown exhibited increased mRNA levels of psoriasis‐associated inflammatory mediators, including Il17a, Il1b, and Cxcl1, in both the dorsal and ear skin (Figure 4F; Figure S4J, Supporting Information), and greater neutrophil infiltration was confirmed by flow cytometry (Figure 4G,H; Figure S4K,L, Supporting Information). The gene discussed is FADS2; the disease is psoriasis.