Notably, the microarray dataset available for patients with psoriasis and IMQ‐induced mouse models both demonstrated significant reductions in FADS1, FADS2, and ELOVL5 expression in psoriatic skin lesions, indicating a conserved defect in PUFA biosynthesis in psoriatic inflammation.[36, 37] In our study, we performed an integrative analysis combining public transcriptomic datasets, RT‐qPCR, and immunofluorescence staining to assess both the mRNA and protein expression levels of key PUFA biosynthetic enzymes (FADS2, FADS1, and ELOVL5) in psoriatic skin. The gene discussed is FADS2; the disease is psoriasis.