Given that previous studies have implicated PUFA in the pathogenesis of psoriasis,[7, 16, 17, 18] and our previous transcriptomic analysis revealed dysregulation of fatty acid metabolism pathways in psoriasis, with markedly reduced FADS2 expression in psoriatic lesions,[19] we hypothesized that FADS2 might play a protective role in psoriasis. This evidence concerns the gene FADS2 and psoriasis.