WY14643 treatment significantly downregulated psoriasis‐associated inflammatory cytokines and chemokines (Il17a, Il1b, Cxcl1, Cxcl2, Cxcl3, Cxcl15, and Csf3) as well as the antimicrobial peptides S100a8 and S100a9 in IMQ‐induced skin lesions at the transcriptional level (Figure 7K). Here, S100A8 is linked to psoriasis.