Here we show that MPNST cells secrete factors that lead to acquisition of M2 markers (CD206, CD163, MGL-1, MMP-9, VEGF-A, ARG and GS) by macrophages, enabling their induction of cancer cell growth and motility and of endothelial cell angiogenesis. The gene discussed is LLGL1; the disease is malignant peripheral nerve sheath tumor.