A master regulator of this metabolic rewiring is the mitochondrial chaperone TRAP1: by driving succinate accumulation, it elicits the ensuing stabilization of the pro-neoplastic transcription factor HIF-1α [7], and TRAP1 targeting with newly identified and selective inhibitors impairs neoplastic growth of MPNST cells [8]. The gene discussed is TRAP1; the disease is malignant peripheral nerve sheath tumor.