This dysregulation is associated with a variety of disorders, such as Aicardi—Goutières syndrome (AGS), STING—associated vasculopathy with infantile onset (SAVI), ulcerative colitis, non—alcoholic fatty liver disease (NAFLD), and amyotrophic lateral sclerosis (ALS) [405–410]. The gene discussed is STING1; the disease is amyotrophic lateral sclerosis.