In the context of myocardial infarction or myocardial I/R injury, DAMPs such as HMGB1, HSPs, mtDNA, and ATP promote cellular focal death by activating the NLRP3 inflammasome, caspase-1, caspase-4/5/11, and GSDMD [272, 309]. This evidence concerns the gene NLRP3 and myocardial infarction.