Luo et al. reported that the cGAS-STING pathway is activated in a lipopolysaccharide (LPS)-induced mouse model of sepsis-associated acute kidney injury, and administration of the cGAS inhibitor RU.521 or the STING inhibitor DMXAA can alleviate renal damage in this model (Luo et al. 2024). The gene discussed is STING1; the disease is Sepsis.