Elevated plasma GFAP and NfL at baseline were significantly associated with accelerated cognitive decline in the cortical volumes of the fusiform cortex, superior frontal gyrus, and pars opercularis after FDR correction (P < 0.05) (Fig. 3A; Supplementary Table 8) as well as with accelerated cognitive decline in cortical areas in the fusiform cortex, superior frontal gyrus, and pars opercularis (Supplementary Table 9). The gene discussed is NEFL; the disease is Mental deterioration.