In some CH subtypes (CALR, DNMT3A_R882, DNMT3A_other, JAK2 and SRSF2) these effects were driven largely by large clones, whereas other CH subtypes (ASXL1, PPM1D and TET2) showed a more dose-dependent association between VAF and measured LTL (Supplementary Fig. 1 and Supplementary Table 9). Here, PPM1D is linked to cyclic hematopoiesis.