This confirmed the reported association of higher LTL-PRS (predictive of longer LTL) with increased prevalence of several common CH subtypes such as those driven by DNMT3A, TET2 and JAK2 mutations, and with CH associated with autosomal mosaic chromosome alterations (mCAs) (Fig. 1b and Supplementary Table 1). The gene discussed is DNMT3A; the disease is cyclic hematopoiesis.