This revealed that, for most CH subtypes, including DNMT3A-CH, TET2-CH, ASXL1-CH, JAK2-CH and CALR-CH, low-VAF samples had LTLs close to controls without CH whereas high-VAF samples had shorter LTLs, presumably reflecting telomere attrition during clonal expansion (Fig. 2b). This evidence concerns the gene DNMT3A and cyclic hematopoiesis.