Sex-specific survival analysis between APOE and SNAP25 measured plasma protein levels and prospective dementia showed a significant association for APOE both in males (hazard ratio (HR) = 0.68, p-value = 3.89E-10) and females (HR = 0.67, p-value = 5.64E-13), but with non-significant sex-dimorphic effect (p-value = 0.94). This evidence concerns the gene APOE and dementia.