ACTL6A (also known as BAF53A and INO80K) is a shared subunit of the SWI/SNF and INO80 complexes and functions as a driver of colorectal cancer (CRC), glioma, squamous cell carcinoma (SCC), hepatocellular carcinoma [21–24]. The gene discussed is ACTL6A; the disease is colorectal carcinoma.