The overexpression of NPRA exhibited a significant relationship with the concentrations of VEGF-A, a pro-angiogenic factor, and the pro-lymphangiogenic factor, VEGF-C, suggesting that NPRA may contribute to the development of tumor vasculature and lymphangiogenesis by modulating the VEGF pathway, which in turn enhances invasion and metastasis. The gene discussed is NPR1; the disease is neoplasm.