The study reported by Li et al. [40] found that lncRAN MRCCAT1 epigenetically reduces the activity of NPRC transcription through the recruitment of PRC2 to the NPRC gene regulatory sequence, thereby enhancing the H3K27me3 modification the repression of NPRC leads to an elevated level of p38-MAPK phosphorylation and promotes tumor metastasis. This evidence concerns the gene NPR3 and neoplasm.