NPR1 and benign prostatic hyperplasia: Wang et al. [1] illustrated that NPRA was significantly highly expressed in tumorigenic prostate cells (e.g., PC3, DU145, and TRAMP-C1), while it was barely expressed in normal PrEC and BPH cells, and NPRA expression was positively correlated with prostate cancer stage (e.g., Gleason score) and androgen-independent (AI) status.