We have developed a novel peptide (ELD607) that specifically inhibits Orai1, which we evaluated in CF neutrophils.<h4>Objectives</h4>To characterize Orai1/SOCE in neutrophils from pwCF taking ETI, and to evaluate the impact of SOCE inhibition by ELD607 on pwCF neutrophil Ca<sup>2+</sup> signaling/function.<h4>Methods</h4>Peripheral blood neutrophils were isolated by negative selection. This evidence concerns the gene ORAI1 and cystic fibrosis.