HSP90AB1 and early-onset autosomal dominant Alzheimer disease: It is now well established that chaperones such as HSP90, GRP94, and HSC70 form the core of epichaperome assemblies in multiple diseases, including Alzheimer’s disease [14,17], Parkinson’s disease [58,62], traumatic brain injury [60], and various cancers [8,10,15,16,57,67,68].