Unsupervised clustering of HVGs revealed tissue-associated expression patterns: BM-derived tumor cells presented increased expression of genes related to the cell cycle (CCND3, MYC, and CDK14), BCR/NF-κB signaling (NFKB2, NFKBIA/B/D/Z, CARD11, and REL) and B cell development (BCL6, FOXO1, IRF4, IRF8, and GNA13), whereas tumor cells from other tissues exhibited elevated expression levels of genes linked to DNA repair (ATM and PARP1), histone modifications (MEF2B, POU2F2, and HIST1H2AC), and BCR/NF-κB signaling (CD79B, PLCG2, and SYK) (Figure S2D). The gene discussed is IRF8; the disease is neoplasm.