NFKB1 and mantle cell lymphoma: Other common alterations in MCL include loss-of-function mutations in ATM and TP53. 14,15 Additionally, recurrent mutations in genes involved in epigenetic modification (KMT2D and TERT), the cell cycle (CDKN2A and MYC), apoptosis (BIRC3 and BCL2), B-cell receptor (BCR)/nuclear factor κB (NF-κB) signaling (CARD11 and NFKBIE), NOTCH signaling (NOTCH1 and NOTCH2), and other genes, such as UBR5 and S1PR1, have been identified.14