ADAM28, a putative proinflammatory molecule, has multiple effects on the immune system, cell migration, and cancer21; CD70, a possible MSC marker, was also ascribed proinflammatory effects22; and AMIGO-3 plays a possible role in preventing re-myelination.23 We found CD4, which can be present on MSCs,24 to be expressed at higher levels in MS MSCs, but we decided not to validate this observation, to avoid potential effects on the T cells during this interaction that would mask MSC effects (Figure 4, black-boxed genes). This evidence concerns the gene CD70 and myeloid sarcoma.