First, we analysed the frequency of TP53 mutation in 10 types of cancer, including esophageal cancer (ESCA), pancreatic adenocarcinoma (PAAD), colorectal adenocarcinoma (COAD), LUAD, bladder cancer (BLCA), stomach adenocarcinoma (STAD), EC, breast invasive carcinoma (BRCA), HCC and prostate adenocarcinoma (PRAD). Here, TP53 is linked to esophageal cancer.