First, we analysed the frequency of TP53 mutation in 10 types of cancer, including esophageal cancer (ESCA), pancreatic adenocarcinoma (PAAD), colorectal adenocarcinoma (COAD), LUAD, bladder cancer (BLCA), stomach adenocarcinoma (STAD), EC, breast invasive carcinoma (BRCA), HCC and prostate adenocarcinoma (PRAD). The gene discussed is TP53; the disease is hepatocellular carcinoma.