Univariate Cox regression followed by LASSO Cox regression was used for identification of prognostic gene signature consisted of eight MCC genes, BCAT1, DPF1, CDKN2B, CDKN2C, TUBA3C, IGF1, CDC14B and SMARCA2, that predicted overall survival of HCC patients. The gene discussed is CDKN2B; the disease is hepatocellular carcinoma.