A study determined the role of DNA gyrase mutations in Pre-XDR AND XDR-TB clinical isolates revealed that all Pre-XDR-TB and XDR-TB isolates carried at least one mutation within the quinolone resistance-determining region of DNA gyrase [60].Thisvariation could be due to the meta-analysis nature of the study based on diverse patient populations in various settings, geographic differences, methods of detection, and epidemiological factors that contribute to drug resistance. Here, TOP2A is linked to tuberculosis.