Nevertheless, the findings in normotensive patients with ADPKD are still controversial.17,18,80, , –83 Given that the present series consisted of young, normotensive patients with ADPKD with preserved renal function, the higher levels of uAGT support overactivity of intrarenal RAS already in the early stages of the disease, as evidenced in experimental models,84 representing a prognostic biomarker of future hypertension in the context of ADPKD. This evidence concerns the gene DPAGT1 and hypertensive disorder.