Therefore, uAGT had already been suggested as an effective biomarker of intrarenal RAS overactivity in hypertension.79 Studies in patients with ADPKD have disclosed increased uAGT, especially among hypertensive older patients.80,81 Interestingly, Salih et al.82 observed that increased levels of uAGT was more associated with hypertension in later stages of ADPKD when compared with CKD of other etiologies, suggesting that this biomarker is associated with ADPKD itself. This evidence concerns the gene DPAGT1 and autosomal dominant polycystic kidney disease.