ESCO2 and pemphigus foliaceus: We show that selective inhibition of cytokinesis or migration (by deletion of Ect2) or induction of cell death in proliferating cells (by deleting Esco2) in cells derived from alveolar fibroblasts diminished the formation of pathologic fibroblast clusters, reduced collagen accumulation, and rescued organ function in 2 in vivo models of PF.