In two sub-studies of the BARICO (Bariatric Surgery Rijnstate and Radboudumc Neuroimaging and Cognition in Obesity) study, it was found that cognitive improvement post-surgery was indeed associated with lower systemic inflammation, lower leptin levels, higher adiponectin levels, improved mood and PA 6 and 24 months post-surgery[11, 12]. Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.