On the other hand, diseases such as SjD may be missed or diagnosed late (pSjD is often diagnosed using European League Against Rheumatism (EULAR) SS (SjD) Patient Reported Index (ESSPRI) and the EULAR SS (SjD) Disease Activity Index (ESSDAI) [86], lip/salivary gland biopsies and blood tests for specific autoantibodies – e.g. anti-Ro/SSA, anti-La/SSB, rheumatoid factor (RF) [87]), delaying systemic care and increasing the risk of complications (e.g. development of lymphoproliferative disorders [88, 89], dental caries, corneal ulcers). The gene discussed is CALR; the disease is dental caries.