A recent study identified that the TNF‐NF‐κB‐p53 axis restricts in vivo survival of hPSC‐derived dopamine neurons in PD models.[47] While our findings highlighted that the enrichment of TNF‐NF‐κB signaling in host C3+ astrocytes may affect transplanted NSCs' survival through non‐cellular autonomous toxicity. The gene discussed is TNF; the disease is Parkinson disease.