S100A9 and hypertriglyceridemia: Mice overexpressing S100A9 in the context of intact TRL4 (ie, ID;Tlr4WT;S100A9OE mice) had improved hypertriglyceridemia as compared to ID;Tlr4WT mice; however, this effect of S100A9 was blunted in the context of TRL4 deficiency (ie, ID;Tlr4KO;S100A9OE mice) (Fig. 4D).