Hence, our data shown in Fig. S5H and S5I (59), indicating that ID mice expressing TLR4 only in BM and BM-derived immune cells do not respond to the hyperketonemia- and hypertriglyceridemia-lowering actions of S100A9, further corroborate the notion that TLR4 in KCs underpins the ketone and lipid improving effect of S100A9. This evidence concerns the gene TBCE and hypertriglyceridemia.