Secondly, to elucidate whether MCPIP1 affected PC metastasis and development, we interfered with MCPIP1 expression and examined functional phenotypes associated with hybrid EMT and tumor stemness through in vivo and in vitro experiments, which clarified that MCPIP1 played a role in inhibiting the malignant behavior of PC by acting through the IL6/JAK2/STAT3 signaling axis. Here, JAK2 is linked to pachyonychia congenita.