Among multiple reports, both FTO and ALKBH5 are linked to cancer, FTO is linked to obesity [16, 23], and ALKBH5 is linked to regulation of the hypoxic response and is a hypoxia-inducible factor target gene, i.e. is upregulated in hypoxia [78]. The gene discussed is FTO; the disease is obesity due to melanocortin 4 receptor deficiency.