SIRT1 and pancreatitis: Increasing evidence suggests that Sirt1 serves as a protective factor in pancreatitis, with Sirt1 agonists shown to suppress both inflammation and fibrosis in this condition.[30, 31, 32] Notably, Sirt1 is significantly upregulated in human CP samples.[33] Given the complexity of Sirt1's functions, we hypothesized that systemic knockout might obscure its role in the MMT process.