It controls not only the number and secretion of insulin and glucagon from pancreatic α and β cells but also pancreatic development.[4] Furthermore, UCP2 knockdown significantly inhibits the proliferation of pancreatic stellate cells (PSCs) in pancreatitis.[5] Importantly, UCP2 mediates glutamine/aspartate metabolism, influencing pancreatic cancer progression.[6] These findings suggest that UCP2 may be a crucial regulatory gene in pancreatic diseases; however, its role in CP remains unexplored. This evidence concerns the gene UCP2 and pancreatic neoplasm.