TGFB1 and neoplasm: Macrophages can induce LD formation, with the accumulation of these droplets aiding in the phagocytosis of long‐chain fatty acids, thus inhibiting tumor cells' lipid metabolism.[43] Conversely, emerging evidence indicates that LD can directly regulate macrophage function, independent of energy alterations resulting from lipid metabolic reprogramming.[40, 44] Our research demonstrates that LD released by pancreatic acinar cells drives the macrophage MMT process more effectively than TGF‐β stimulation.