Sertraline increased HuH7 HCC cell migration in response to TGF‐α, similar to duloxetine and fluvoxamine (SSRIs), but not reboxetine (NRI), suggesting a serotonin‐specific effectSertraline activated JNK phosphorylation without affecting p38 MAPK or AKTJNK inhibition (SP600125) blocked migration, confirming JNK's roleFindings suggest sertraline promotes HCC cell migration via serotonin‐mediated JNK activation, raising concerns about potential cancer progression. Here, MAPK8 is linked to hepatocellular carcinoma.