Sertraline significantly inhibited melanoma cell proliferation in a dose‐dependent mannerIt downregulated the Akt signaling pathwaySertraline induced ER stress, leading to apoptosis in melanoma cellsIn vivo, sertraline monotherapy modestly reduced melanoma tumor growth, but the effect was not statistically significantThe study suggests that sertraline may enhance the efficacy of existing melanoma treatments by inhibiting Akt and inducing ER stress. The gene discussed is AKT1; the disease is neoplasm.