TCTP is significantly downregulated during tumor reversion Inhibition of TCTP reduces malignancy in multiple solid tumorsSertraline and other neuroleptic/antihistaminic compounds lower TCTP levels and induce cancer cell deathIn vivo, sertraline suppresses tumor growth in SCID mice without causing toxicitySertraline's anticancer effects are linked to TCTP inhibition, supporting its repurposing potentialTCTP silencing induces flat revertants in transformed fibroblasts, confirming its role in malignancy reversal. This evidence concerns the gene TPT1 and neoplasm.