Cetuximab is a chimeric monoclonal antibody that contains alpha-gal and can lead to allergic reactions in individuals with alpha-gal syndrome.<h4>Methods</h4>A 66-year-old with metastatic squamous cell carcinoma of the right tonsil with involvement of the lung and liver was planned to receive palliative therapy with cetuximab. This evidence concerns the gene GAL and squamous cell carcinoma.