PDCD1 and hepatocellular carcinoma: demonstrated that TREM2+ macrophages are immunosuppressive and associated with poor prognosis and reduced responses to anti‐PD‐1 therapy in NSCLC.[158] Moreover, TREM2+ macrophages were shown to inhibit CD8+ T‐cell infiltration in hepatocellular carcinoma (HCC).[159] In contrast, pro‐inflammatory macrophages, characterized by CXCL9 and CXCL10, were found to be closely associated with CXCL13+ T cells and IFN‐γ responses in TNBC, suggesting active anti‐tumor immunity within the TME.[96] Additionally, Ramos et al.