TCF7 and neoplasm: used in vivo labeling to demonstrate the continuous trafficking of TCF‐1+ T cells between the tumor and TDLNs.[145] These results suggest that specific T cell subsets in TDLNs, particularly those with stem‐like properties marked by TCF1/TCF7, can further differentiate and infiltrate into tumors, thereby continuously replenishing the T cell pool in the TME (Figure 3).