CD4 and neoplasm: reported similar findings in bile duct and pancreatic cancers, where both neoantigen‐reactive CD8+ T cells, co‐expressing CXCL13 and GZMA, and neoantigen‐reactive CD4+ T cells, overexpressing HOPX or ADGRG1 and lacking IL7R expression, display an exhausted phenotype.[88] These studies suggest that tumor‐reactive T cells are frequently associated with tissue‐resident or dysfunctional/exhausted phenotypes, underscoring the prevalence of Tex and Trm‐like populations.