CD4+ T cells are increasingly recognized as crucial mediators of anti‐tumor immunity, yet their functional diversity remains incompletely characterized, though emerging evidence highlights their complex crosstalk with B cells as a critical determinant of ICI efficacy.[121, 151] We also offer a comprehensive review of additional immune cell components, including macrophages, DCs, B cells, and neutrophils, focusing on their intricate interactions with T cells within the TME. This evidence concerns the gene CD4 and neoplasm.