CD4 and neoplasm: identified distinct, conserved cellular neighborhoods (CNs) within the CRC TME, revealing that the presence of CD4+ PD‐1+ T cells within a granulocyte CN is positively correlated with survival, whereas the coupling of tumor and immune CNs, fragmentation of T cell and macrophage CNs, and disruption of inter‐CN communication are linked to poor clinical outcomes.[256] Furthermore, Pelka et al.