demonstrated that tumor‐infiltrating neutrophils exert direct anti‐tumor effects through secretion of catalytically active neutrophil elastase, which selectively induces cancer cell death, inhibits primary tumor progression, and elicits systemic anti‐tumor immunity by activating CD8+ T cell‐dependent abscopal effects against metastatic lesions.[191] Similarly, Faraoni et al. This evidence concerns the gene ELANE and neoplasm.