found that intratumoral DC‐CD4+ Th cell niches promote CD8+ T cell differentiation, with progenitor CD8+ T cells interacting with CXCL13+ Th cells and mregDCs, forming cellular triads that enhance anti‐tumor responses upon PD‐1 blockade in HCC.[255] Schürch et al. Here, PDCD1 is linked to hepatocellular carcinoma.