VEGFA and renal cell carcinoma: Von Hippel‐Landau (VHL) tumor suppressor gene holds a pivotal role in the overall pathophysiology of RCC, which is expressed by 3p25 genetic locus.[34] Inactivation or absence of VHL leads to increased production of growth factors, such as vascular endothelial growth factor (VEGF), transforming growth factor (TGF), platelet‐derived growth factor (PDGF), and others.