Von Hippel‐Landau (VHL) tumor suppressor gene holds a pivotal role in the overall pathophysiology of RCC, which is expressed by 3p25 genetic locus.[34] Inactivation or absence of VHL leads to increased production of growth factors, such as vascular endothelial growth factor (VEGF), transforming growth factor (TGF), platelet‐derived growth factor (PDGF), and others. The gene discussed is VHL; the disease is renal cell carcinoma.