These included multitrait colocalization at 6 loci with a consistent direction of effect between CAD and cancer (ABO, PGAP3, ANGPTL4, SREBF1, HAUS6, and SYNJ2BP) and 7 with an opposing direction (CDKN1A, RGS19, CALCRL, SF3A3, LAMC1, MYO9B, and MIA3; Table S17). This evidence concerns the gene SREBF1 and coronary artery disorder.