Among 133 genes mapped to lead SNPs at 60 colocalized pleiotropic loci or variants in high LD (r2>0.80) with these SNPs, 6 had evidence of being interacting genes for breast cancer (APOC3-COG5, CDKN1A-TERT, DCLRE1B-TERT, and ZEB2-TERT), 6 for colorectal cancer (ANGPTL4-LOX, ERBB2-LOX, NOS3-LOX, and SF3A3-SNRPC), and 10 for prostate cancer (ATPAF2-DRC3, CHD3-RAI1, HDAC9-MIA3, MYO9B-SH2B3, and PPL-SPINT2; Figures S1 through S3). The gene discussed is SPINT2; the disease is colorectal cancer.