However, the activity of the PI3K/Akt pathway in autism is not entirely consistent, with (Nicolini et al. 2015); (Yadollahi-Farsani et al. 2024); and Wang L. et al. (2024) confirming our findings that PI3K activity is significantly reduced in ASD, while (Thomas et al. 2023); (Sharma et al. 2022); (Li et al. 2024); and Zhang W. et al. (2020) found the opposite. This evidence concerns the gene AKT1 and autism.