PSD95, as the major scaffolding protein at glutamatergic synapses, critically regulates AMPA receptor anchoring and synaptic currents (Ziółkowska et al., 2023), with its aberrant expression potentially contributing to excitation-inhibition (E/I) imbalance in neurodevelopmental disorders like ASD (Keith and El-Husseini, 2008). Here, DLG4 is linked to neurodevelopmental disorder.