miR-145-5p is an important regulator of cardiac hypertrophy, in contrast, miR-145-5p is a well-established inhibitor of cardiac hypertrophy, suppressing pro-hypertrophic pathways by targeting genes such as GATA6 and IGF1R (Li et al., 2013; Lin et al., 2021). Here, IGF1R is linked to cardiac hypertrophy.