NUP214 and cardiac hypertrophy: Increased levels of intracellular Ca2+ can activate CaN, and activated CaN dephosphorylates transcription factors of the NFAT family and translocates them to the nucleus, promoting the binding of NFAT to DNA and its interaction with other transcription factors, thereby activating genes related to cardiac hypertrophy and ultimately leading to cardiac hypertrophy (Wilkins and Molkentin, 2004).