While the tumor-suppressive function of LKB1 is well-established in several cancers, most notably lung adenocarcinoma and Peutz-Jeghers syndrome (Ji et al., 2007; Tacheci et al., 2021), the biology of LKB1 in PCa displays unique patterns (Kang et al., 2024). Here, STK11 is linked to Peutz-Jeghers syndrome.