Preclinical models have demonstrated that LKB1 deficiency synergizes with potent oncogenes, e.g., Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) mutations, to promote rapid tumor growth, metabolic deregulation, and metastatic dissemination (Morton et al., 2010; Caiola et al., 2018). Here, STK11 is linked to neoplasm.