NPPB and type 1 diabetes mellitus: (69) followed up 960 T1DM patients with normal EF for 6.3 years, and found that echocardiographic E/E’ ratios in conjunction with serum NT-proBNP levels identified a population with very high cardiovascular risk (NT-proBNP >300 pg/mL and E/e′>12) and may provide a low-cost, easily accessible tool for accurate clinical stratification.