This review systematically integrates the latest research progress on novel molecular markers (e.g., soluble suppression of tumorigenicity 2 [sST2], adiponectin [APN], and develops strategies for “molecular marker combinations” and “integration of molecular markers with imaging technologies” to provide a theoretical basis for the early and accurate diagnosis of DCM. Here, ANPEP is linked to familial dilated cardiomyopathy.