Micro-CT, and H&E, and Masson staining results showed that knockdown of LINC00657 significantly inhibited the anti-osteoporosis effect of UNC0638, including a decrease in four bone indices (BMD, BV/TV, Tb.Th, and Tb.N) and an increase in three indices (BS/BV, Tb.Sp and SMI) (Figure 5H, p < 0.05; and Figure 6A). The gene discussed is NORAD; the disease is osteoporosis.