In Model II, which adjusted for potential confounders including sex, BMI, age, drinking status, Hs-CRP, ALT, SBP, physical activity, smoking status, Scr, GGT, LDL-c, AST, HTN, DLP-MED, and HTN-MED, the positive association between AIP (per 0.1 unit) and the risk of pre-DM remained, with an SHR of 1.09 (95% CI: 1.04–1.14). This evidence concerns the gene CRP and diabetes mellitus.