Alb; albumin; BMI, body mass index; BNP, brain natriuretic peptide; eGFR, estimated glomerular filtration rate; Hb, hemoglobin; HFpEF, heart failure with preserved ejection fraction; IHD, ischemic heart disease; LVEF, left ventricular ejection fraction; NYHA, New York Heart Association; VHD, valvular heart disease. This evidence concerns the gene NPPB and heart valve disorder.