TP53 and colorectal carcinoma: We divided these factors into modifiable and non-modifiable factors; among the non-modifiable risk factors, age > 55 years, family history of CRC, male gender, family history of malignancy, and genetic mutation (single-nucleotide polymorphism (SNP), KRAS, p53, linkage disequilibrium, and klotho) were the most reported risk factors across the included studies.