In addition to ADPKD, the most common inherited kidney disease [90], the protein content of uEVs has also been investigated in a rare genetic disorder [84]: autosomal dominant tubulointerstitial kidney disease-subtype hepatocyte nuclear factor 1β (ADTKD-HNF1β) is caused by mutations in the HNF1β gene leading to renal and extrarenal manifestations [84]. Here, HNF1B is linked to kidney disorder.