IL6 and alkaline phosphatase measurement: Recently, few studies have established an prediction model to identify APALI in patients with AP, for instance, Samanta et al. (10) proposed IL-6 and IL-8 as potential biomarkers for lung injury in AP, while Jia et al. (11) developed a nomogram-based tool using routine clinical data—however, both studies were limited by small sample sizes and lacked external validation.