Specifically, HSA/Se NPs inhibit mitochondrial‐related apoptosis through the activation of the Keap1‐Nrf2‐SOD pathway and the Bcl‐2‐cytochrome C‐caspase pathway, suppressing ferroptosis by activating the GPX4‐SLC7A11‐GSH pathway in a PD model. Here, GPX4 is linked to Parkinson disease.